Early water breakthrough and a rapid increase in water cut are always observed in highpermeability completion intervals when perforations are uniformly distributed in the wellbore in heterogeneous reservoirs. Optimization of perforating parameters in partitioned sections in horizontal intervals helps homogenize the inflow from the reservoir and thus is critically important for enhanced oil recovery. This paper derives a coupled reservoir-wellbore flow model based on inflow controlling theory. Genetic algorithms are applied to solving the model as they excel in obtaining the global optimum of discrete functions. The optimized perforating strategy applies a low perforation density in highpermeability intervals and a high perforation density in low-permeability intervals. As a result, the inflow profile is homogenized and idealized.