The rapid changing near source, multi-stream depositional environment of conglomerate reservoirs leads to severe heterogeneity, complex lithology and physical properties, and large changes of oil layer resistivity. Quantitative evaluation of water-flooded layers has become an important but diffi cult focus for secondary development of oilfields. In this paper, based on the analysis of current problems in quantitative evaluation of water-flooded layers, the Kexia Group conglomerate reservoir of the Sixth District in the Karamay Oilfield was studied. Eight types of conglomerate reservoir lithology were identifi ed effectively by a data mining method combined with the data from sealed coring wells, and then a multi-parameter model for quantitative evaluation of the water-flooded layers of the main oil-bearing lithology was developed. Water production rate, oil saturation and oil productivity index were selected as the characteristic parameters for quantitative evaluation of water-flooded layers of conglomerate reservoirs. Finally, quantitative evaluation criteria and identification rules for water-flooded layers of main oil-bearing lithology formed by integration of the three characteristic parameters of water-flooded layer and undisturbed formation resistivity. This method has been used in evaluation of the water-flooded layers of a conglomerate reservoir in the Karamay Oilfield and achieved good results, improving the interpretation accuracy and compliance rate. It will provide technical support for avoiding perforation of high water-bearing layers and for adjustment of developmental programs.