A powerful method is necessary for thermodynamic modeling of wax phase behavior in crude oils, such as the perturbed-chain statistical associating ?uid theory (PC-SAFT). In this work, a new approach based on the wax appearance temperature of crude oil was proposed to estimate PC-SAFT parameters in thermodynamic modeling of wax precipitation from crude oil. The proposed approach was veri?ed using experimental data obtained in this work and also with those reported in the literature. In order to compare the performance of the PC-SAFT model with previous models, the wax precipitation experimental data were correlated using previous models such as the solid solution model and multi-solid phase model. The results showed that the PC-SAFT model can correlate more accurately the wax precipitation experimental data of crude oil than the previous models, with an absolute average deviation less than 0.4 %. Also, a series of dynamic experiments were carried out to determine the rheological behavior of waxy crude oil in the absence and presence of a ?ow improver such as ethylene–vinyl acetate copolymer. It was found that the apparent viscosity of waxy crude oil decreased with increasing shear rate. Also, the results showed that the performance of ?ow improver was dependent on its molecular weight.