The mechanistic understanding of the reactions that govern the inhibitor retention and release, modeling, and the state-of-the-art innovation in squeeze treatment are reviewed. The retention and release are governed by (1) the amount of calcite that can dissolve prior to inhibitor-induced surface poisoning; (2) calcite surface poisoning after ~ 20 molecular layers of surface coverage by the adsorbed inhibitors to retard further calcite dissolution; (3) less base, CO2−3, is released into the aqueous solution; (4) formation of the more acidic inhibitor precipitates; (5) phase transformation and maturation of the more acidic inhibitor precipitates; and (6) dissolution of the less soluble crystalline inhibitor precipitates. The trend to advance squeeze technologies is through (1) enhancing scale inhibitor retention, (2) optimizing the delivery of scale inhibitors to the target zone, and (3) improving monitoring methods. Lastly, a prototype yardstick for measuring the squeeze performance is used to compare the squeeze life of 17 actual squeeze treatments. Even though the various squeeze treatments appear to be different, all published squeeze durations can be rated based on the normalized squeeze life per unit mass of inhibitors.