Abstract: In addition to the temperature and pressure conditions, the pore fluid composition and migration behavior are also crucial to control hydrate decomposition in the exploitation process. In this work, to investigate the effects of these factors, a series of depressurization experiments were carried out in a visible one-dimensional reactor, using hydrate reservoir samples with water saturations ranging from 20% to 65%. The results showed a linear relationship between gas production rates and gas saturations of the reservoir, suggesting that a larger gas-phase space was conducive to hydrate decomposition and gas outflow. Therefore, the rapid water production in the early stage of hydrate exploitation could release more gas-phase space in the water-rich reservoir, which in turn improved the gas production efficiency. Meanwhile, the spatiotemporal evolution of pore fluids could lead to partial accelerated decomposition or secondary formation of hydrates. In the unsealed reservoir, the peripheral water infiltration kept reservoir at a high water saturation, which hindered the overall production process and caused higher water production. Importantly, depressurization assisted with the N2 sweep could displace the pore water rapidly. According to the results, it is recommended that using the short-term N2 sweep as an auxiliary means in the early stage of depressurization to expand the gas-phase space in order to achieve the highest production efficiency.