Abstract: Kinds of complex-structure wells can effectively improve production, which are widely used. However, in the process of drilling and completion, complex-structure wells with long drilling cycle and large exposed area of reservoir can lead to the fact that reservoir near wellbore is more vulnerable to the working fluid invasion, resulting in more serious formation damage. In order to quantitatively describe the reservoir formation damage in the construction of complex-structure well, taking the inclined well section as the research object, the coordinate transformation method and conformal transformation method are given according to the flow characteristics of reservoir near wellbore in anisotropic reservoir. Then the local skin factor in orthogonal plane of wellbore is deduced. Considering the uneven distribution of local skin factor along the wellbore, the oscillation decreasing model and empirical equation model of damage zone radius distribution along the wellbore direction are established and then the total skin factor model of the whole well is superimposed to realize the reservoir damage evaluation of complex-structure wells. Combining the skin factor model with the production model, the production of complex-structure wells can be predicted more accurately. The two field application cases show that the accuracy of the model can be more than 90%, which can also fully reflect the invasion characteristics of drilling and completion fluid in any well section of complex-structure wells in anisotropic reservoir, so as to further provide guidance for the scientific establishment of reservoir production system.