Abstract: The transmission medium of natural gas gathering and transportation pipelines usually contains corrosive gases, which will cause serious corrosion on the inner wall of the pipelines when they coexist with water. Therefore, it is necessary to add corrosion inhibitor to form a protective film to protect the pipeline. The distribution of corrosion inhibitors in a gathering and transportation pipeline in Moxi gas field was studied by combining experiment and simulation. The Pearson function was used to calculate the experimental and simulation results, and the correlation was more than 80%, indicating a high degree of agreement. The simulation results show that: ① The larger the pipe angle, filling speed and gas flow rate, the smaller the particle size, the better the distribution of corrosion inhibitor particles in the pipe. The filling amount will affect the concentration, but the distribution trend is unchanged; ② A method to determine the filling mode based on the loss was proposed, and for this pipeline, the loss of corrosion inhibitor was determined to be 5.31 × 10−3 kg/s, and the filling amount was recommended to be adjusted to 20 L/h, which has certain guiding significance for the actual filling strategy of pipeline corrosion inhibitor.