Abstract: With the exploration and development of deep and ultra-deep oil and gas, high torque and high friction during the drilling of deep and ultra-deep wells become one of the key issues affecting drilling safety and drilling speed. Meanwhile, the high temperature and high salt problem in deep formations is prominent, which poses a major challenge to the lubricity of drilling fluids under high temperature and high salt. This paper reports an organic borate ester SOP as an environmentally friendly drilling fluid lubricant. The performance evaluation results show that when 1% lubricant SOP is added to the fresh water-based mud, the lubrication coefficient decreases from 0.631 to 0.046, and the reduction rate of lubrication coefficient is 92.7%. Under the conditions of 210 °C and 30% NaCl, the reduction rate of lubricating coefficient of the base slurry with 1% SOP was still remain 81.5%. After adding 1% SOP, the wear volume decreased by 94.11% compared with the base slurry. The contact resistance experiment during the friction process shows that SOP can form a thick adsorption film on the friction surface under high temperature and high salt conditions, thus effectively reducing the friction resistance. Molecular dynamics simulation shows that lubricant SOP can be physically adsorbed on the surface of drilling tool and borehole wall through hydrogen bond and van der Waals force. XPS analysis further shows that SOP adsorbs on the friction surface and reacts with metal atoms on the friction surface to form a chemically reactive film. Therefore, under high temperature and high salt conditions, the synergistic effect of physical adsorption film and chemical reaction film effectively reduces the frictional resistance and wear of the friction surface. In addition, SOP is non-toxic and easy to degrade. Therefore, SOP is a highly effective and environmentally friendly lubricant in high temperature and high salt drilling fluid.