Abstract: The stimuli-responsive anticorrosion coatings have drawn great attention as a prospective corrosion protection approach due to their smart self-repairing properties. In contrast to passive protection mechanism based on post-corrosion microenvironmental changes, a unique active protection strategy based on nanocatalytic oxygen depletion is proposed in this work to inhibit the occurrence of corrosion. Porous Fe–N–C catalysts with outstanding oxygen reduction reaction (ORR) activity (half-wave potential of 0.89 V) is firstly synthesized through pre-coordination with organosilane precursor to obtain homogeneously distributed active sites. When this catalyst is introduced into the coating matrix, uniformly distributed Fe–N–C not only compensates the defects but plays a crucial role in adsorption and consumption of diffused oxygen in the coating. Under this dual action, the penetration of corrosive medium, especially oxygen, through coating to metal substrate is greatly suppressed, resulting in effective corrosion inhibition and a significant increase in corrosion resistance of the composite coating compared to pure epoxy coating. This work provides a new perspective and the starting point for the design of high-performance smart coating with active anticorrosion properties.