Abstract: The prediction of continental tight sandstone gas sweet spots is an obstacle during tight sandstone gas exploration. In this work, the classic physical fluid charging experimental equipment is improved, the combination of the gas migration and accumulation process with the pore network numerical simulation method is investigated, and application of the permeability/porosity ratio is proposed to predict the gas saturation and sweet spots of continental formations. The results show that (1) as the charging pressure increases, the permeability of the reservoir increases because more narrow pore throats are displaced in the percolation process; and (2) based on pore network numerical simulation and theoretical analysis, the natural gas migration and accumulation mechanisms are revealed. The gas saturation of tight sandstone rock is controlled by the gas charging pressure and dynamic percolation characteristics. (3) The ratio of permeability/porosity and fluid charging pressure is proposed to predict the gas saturation of the formation. The ratio is verified in a pilot and proven to be applicable and practical. This work highlights the tight sandstone gas migration and accumulation mechanisms and narrows the gap among microscale physical experiments, numerical simulation research, and field applications.