Abstract: Understanding the quantitative responses of anisotropic dynamic properties in organic-rich shale with different kerogen content (KC) is of great significance in hydrocarbon exploration and development. Conducting controlled experiments with a single variable is challenging for natural shales due to their high variations in components, diagenesis conditions, or pore fluid. We employed the hot-pressing technique to construct 11 well-controlled artificial shale with varying KC. These artificial shale samples were successive machined into prismatic shape for ultrasonic measurements along different directions. Observations revealed bedding perpendicular P-wave velocities are more sensitive to the increasing KC than bedding paralleling velocities due to the preferential alignments of kerogen. All elastic stiffnesses except C13 are generally decreasing with the increasing KC, the variation of C11 and C33 on kerogen content are more sensitive than those of C44 and C66. Apparent dynamic mechanical parameters (ν and E) were found to have linear correlation with the true ones from complete anisotropic equations independent of KC, which hold value towards the interpretation of well logs consistently across formations. Anisotropic mechanical parameters (ΔE and brittleness ΔB) tend to decrease with the reducing KC, with ΔB showing great sensitivity to KC variations. In the range of low KC (<10%), the VP/VS ratio demonstrated a linearly negative correlation with KC, and the VP/VS ratio magnitude of less than 1.75 may serve as a significant characterization for highly organic-rich (>10%) shale, compilation of data from natural organic rich-shales globally verified the similar systematic relationships that can be empirically used to predict the fraction of KC in shales.