Abstract: High resolution of post-stack seismic data assists in better interpretation of subsurface structures as well as high accuracy of impedance inversion. Therefore, geophysicists consistently strive to acquire higher resolution seismic images in petroleum exploration. Although there have been successful applications of conventional signal processing and machine learning for post-stack seismic resolution enhancement, there is limited reference to the seismic applications of the recent emergence and rapid development of generative artificial intelligence. Hence, we propose to apply diffusion models, among the most popular generative models, to enhance seismic resolution. Specifically, we apply the classic diffusion model—denoising diffusion probabilistic model (DDPM), conditioned on the seismic data in low resolution, to reconstruct corresponding high-resolution images. Herein the entire scheme is referred to as SeisResoDiff. To provide a comprehensive and clear understanding of SeisResoDiff, we introduce the basic theories of diffusion models and detail the optimization objective's derivation with the aid of diagrams and algorithms. For implementation, we first propose a practical workflow to acquire abundant training data based on the generated pseudo-wells. Subsequently, we apply the trained model to both synthetic and field datasets, evaluating the results in three aspects: the appearance of seismic sections and slices in the time domain, frequency spectra, and comparisons with the synthetic data using real well-logging data at the well locations. The results demonstrate not only effective seismic resolution enhancement, but also additional denoising by the diffusion model. Experimental comparisons indicate that training the model on noisy data, which are more realistic, outperforms training on clean data. The proposed scheme demonstrates superiority over some conventional methods in high-resolution reconstruction and denoising ability, yielding more competitive results compared to our previous research.