Despite the absence of regional cap rocks in the Lower Paleozoic for the entire Tazhong Low Rise, several sets of effective local cap rocks are well preserved on the Northern Slope. Of these the best is the Ordovician mudstone of the Sangtamu Formation; the second is the Silurian Red Mudstone Member of the Tatairtag Formation and the marl of the Ordovician Lianglitag Formation; and the third is the gray mudstone of the Silurian Kepingtag Formation. The dense limestone of the Ordovician Yingshan Formation and the gypsum of the Middle Cambrian have shown initial sealing capacity. These effective cap rocks are closely related to the distribution of Lower Palaeozoic hydrocarbons in the Tazhong Low Rise. With well-preserved Sangtamu Formation mudstone and its location close to migration pathways, rich Lower Paleozoic hydrocarbon accumulation can be found on the Northern Slope. Vertically, most of the reserves are distributed below the Sangtamu Formation mudstone; areally, hydrocarbons are mainly found in the areas with well-developed Sangtamu Formation mudstone and Lianglitag Formation marl. Burial history and hydrocarbon charging history show that the evolution of Lower Palaeozoic cap rocks controlled the accumulation of hydrocarbon in the Tazhong Low Rise. Take the Red Mudstone Member of the Tatairtag Formation and Sangtamu Formation mudstone for examples: 1) In the hydrocarbon charging time of the Late Caledonian ? Early Hercynian, with top surfaces at burial depths of over 1,100 m, the cap rocks were able to seal oil and gas; 2) During the intense uplifting of the Devonian, the cap rocks with top surfaces at burial depths of 200-800 m and 500-1,100 m respectively were denuded in local areas, thus hydrocarbons trapped in earlier time were degraded to widespread bitumen; 3) In the hydrocarbon charging time of the Late Hercynian and Himalayan, the top surfaces of the cap rocks were at burial depths of over 2,000 m without intense uplifting and denudation thereafter, so trapped hydrocarbons were preserved. Based on cap rocks, the Ordovician Penglaiba Formation and Lower Cambrian dolomite could be potential targets for exploration on the Tazhong Northern Slope, and combined with hydrocarbon migration, less risk would be involved.