Hydraulic fracturing technology can significantly increase oil production from tight oil formations, but performance data show that production declines rapidly. In the long term, it is necessary to increase the development efficiency of block matrix, surfactant-aided imbibition is a potential way. The current work aimed to explain comprehensively how surfactants can enhance the imbibition rate. Laboratory experiments were performed to investigate the effects of wettability, interfacial tension (IFT), and relative permeability as the key parameters underlying surfactant solution imbibition. Two different types of surfactants, sodium dodecyl sulfate and polyethylene glycol octylphenol ether, at varied concentrations were tested on reservoir rocks. Experimental results showed that the oil recovery rate increased with increased wettability alteration and IFT and decreased residual oil saturation. A mechanistic simulator developed in previous studies was used to perform parametric analysis after successful laboratory-scale validation. Results were proven by parametric studies. This study, which examined the mechanism and factors influencing surfactant solution imbibition, can improve understanding of surfactant-aided imbibition and surfactant screening.