Abstract: The long-term stability of CO2 storage represents a pivotal challenge in geological CO2 storage (CGS), particularly within deep saline aquifers characterized by complex fault-block systems. While the injection sites and rate under different fault structures will directly affect the CO2 storage effect and the risk of leakage. This study investigates the Gaoyou Sag in the Subei Basin, a representative fault-block reservoir, through an integrated numerical-experimental approach. A three-dimensional simulation model incorporating multiphase flow dynamics was developed to characterize subsurface transport processes. A novel fault seal capacity evaluation framework was proposed, integrating three critical geological indices (fault throw/reservoir thickness/ caprock thicknesses) with the coupling of formation physical properties, temperature, and pressure for the rational selection of injection sites and rates. The results show that Optimal storage performance is observed when the fault throw is lower than the reservoir and caprock thicknesses. Furthermore, higher temperature and pressure promote the dissolution and diffusion of CO2, while compared to the structural form of faults, the physical properties of faults have a more significant effect on CO2 leakage. The larger reservoir space and the presence of an interlayer reduce the risk of CO2 leakage, and augmenting storage potential. Decreasing the injection rate increases the proportion of dissolved CO2, thereby enhancing the safety of CO2 storage.