Abstract: It remains a great challenge to understand the hydrates involved in phenomena in practical oil and gas systems. The adhesion forces between hydrate particles, between hydrate particles and pipe walls, and between hydrate particles and reservoir particles are essential factors that control the behaviors of clathrate hydrates in different applications. In this review, we summarize the typical micro-force measurement apparatus and methods utilized to study hydrate particle systems. In addition, the adhesion test results, the related understandings, and the applied numerical calculation models are systematically discussed.