The tectonic movement during the deposition of the Es   3   Formation in the Liuzan Area, Nanpu Sag, is complex, and    the multi-episode tectonic-sedimentary evolution led to great spatial-temporal differences in sequence stratigraphic framework    and sedimentary filling patterns. The research into regional sequences cannot meet the needs of fine characterization of sedimen   tation and sand bodies in the study area. Here we addressed these issues by conducting research focusing on the main oil-bearing    formations of middle-upper part of the Es   3   Formation by using division-correlation technology of continental sequence    stratigraphy. The results reveal the sequence architecture and sedimentary filling characteristics of parasequence sets within the    third-order sequence, and clarify its guidance for oil and gas exploration and development. The first to third submembers of    the Es   3   Formation can be divided into two third-order sequences SQ1 and SQ2. The III and II oil-bearing formations are two    progradational subsequence sets of the lacustrine regression system tract in SQ1 during the tectonically quiet period. With the    gradual shallowing of the sedimentary water body, the study area presents the sedimentary evolution characteristics from "small    plain and big front in a fan delta" to balanced development of “plain and front”. The I and 0 oil-bearing formations are two    retrogradational parasequence sets of the lacustrine transgressive system tract in SQ2 during the tectonically active period. With    an increase of the ratio of accommodation space to sediment supply, the study area presents the sedimentary evolution charac   teristics from the balanced development of “plain and front in a fan delta” to shallow and semi-deep lake facies with the gradual    retrogradation of the fan delta. Laterally, the different activity characteristics of boundary faults control the lateral changes of    the sedimentary environment in the same sedimentary period. The sedimentary characteristics of parasequence sets control the    development of favorable reservoir-cap assemblages in the study area. The middle-late stage of the lacustrine regression system    tract (the III and II oil-bearing formations) and the early stage of the lacustrine transgressive system tract (the I oil-bearing    formation) during the tectonically quiet period are favorable for the deposition of thick reservoir rocks, associated with lacustrine    transgressive mudstone (the 0 oil-bearing formation) deposited at the end of the tectonically active period. These form a favor   able reservoir-cap combination. The architecture characteristics of parasequence sets control the distribution of parasequences    and their internal sand bodies and fluids. The sand bodies in the lower part of the retrogradational parasequence sets are more    developed, showing the characteristics of lower oil and upper water. The top of the parasequence unit is the distribution location    of favorable reservoir sandbodies and hydrocarbon. Through this study, we reveal the sequence architecture and sedimentary    filling modes of the 0~III oil-bearing formations in the middle-upper part of the Es   3   Formation, which provides guidance for the    prediction of sand body distribution and the exploration and development of lithologic reservoirs.