Pipeline is an effective way to convey large-volumn hydrogen for long distance. However, due to high investment and operating costs, it is not easy to transport hydrogen by pipelines. At this stage, a techno-economic model can carry out pre-feasibility and feasibility assessment on each stage of the pipeline, and describe the technical content and characteristics of the pipeline. For hydrogen pipeline, the existing domestic and foreign research on hydrogen pipeline generally regards the hydrogen pipeline as a transportation mode of the transportation link in the hydrogen supply chain process for macro supply chain system optimization, but cannot reflect the detailed technical characteristics and market changes of the pipeline. This has led to significant changes in the cost of hydrogen pipelines. Aming at this issue, this paper combines with the technical characteristics of existing pipelines and cost analysis method to develop a technical-economic model, analyzes the relationship between the main composition cost of hydrogen pipeline, the levelized cost of hydrogen pipeline and the transportation scale, and uses the levelized cost of hydrogen as the analysis index to compare the transportation mode of hydrogen pipeline with that of long-pipe trailer, natural gas hydrogen blending pipeline and liquid hydrogen tank car. Finally, the investment and construction cost range and levelized cost range of domestic hydrogen pipeline will be obtained. In addition, this paper proposes the main ways to reduce the transportation cost of hydrogen pipeline, mainly including increasing the scale of hydrogen transportation, reforming the existing oil and gas pipeline and optimizing the transportation mode layout including hydrogen pipeline. The research results show that: ① When the design throughput is the demand in 2040, the operation result of the hydrogen pipeline is to select the DN500 hydrogen pipeline for transportation, and the pressure of the stations along the line meets the requirements and the flow rate of the pipeline is within the safe range. ② Given the design capacity, the total construction investment range is 9.66×108 ~35.43×108 CNY for 150~155 km pipelines. ③ The levelized transportation cost of hydrogen pipeline increases with the increase of transportation distance but is no more than 10.12 CNY/kg when the transportation scale is constant. ④ Compared with long tube trailers and liquid hydrogen tankers, the cost of hydrogen pipeline transportation has price advantage under given transportation scale and different transportation distance, and the price range is 2.76 ~10.12 CNY/kg. The research results can provide the basis for the cost estimation of pure hydrogen pipeline, have important significance for the reasonable selection of hydrogen pipeline project investment and economic benefit evaluation and comparative analysis, and provide reference for pipeline construction.