Horizontal well multi-stage fracturing is one of the necessary technologies for unconventional oil and gas development. Clarifying multi-cluster fracture propagation and the main control factors of the fluid shunt are crucial to optimizing the stages and cluster design. In this paper, firstly, the original logging data and logging interpretation data at each perforation cluster are obtained. Then, based on distributed optical fiber monitoring technology, the data of the fracturing sequence, liquid inlet ratio, and liquid production ratio of each fracture in the stage are calculated. The well logs and optical fiber monitoring data are compared and analyzed to determine the main controlling factors affecting the multi-cluster fracturing effect in the stage. The results show that the perforated clusters with low minimum principal stress and high brittleness index are opened first. The four most critical factors affecting the proportion of pre-liquid and the sand liquid are: QL> Neutron> Gamma Ray> Acoustic; The research results of this paper have significance for guiding formulation of a fracturing scheme for horizontal wells.